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pentobarbital will decrease the level or effect of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Double brexpiprazole dose over one-2 months if administered with a robust CYP3A4 inducer.pentobarbital will lower the extent or effect of eltrombopag by affecting hepatic enzyme CYP2C9/ten metab